No comfort from the start
For some of us there has been no comfort zone from the beginning. A lioness licks its cubs all over their bodies, stimulating breathing and digestion and a feeling of wellbeing. The cub then is set up to know what it needs from life to feel content. As a child I had asthma which meant my very relationship with breathing was compromised. For some of us, there was no comfort zone from the start.
The only plus from this bad start is that one is forced to seek the ultimate cures because nothing else will satisfy.